Risiko penurunan tekanan darah secara signifikan dapat meningkat jika sildenafil dikonsumsi bersama riociguat atau obat sejenisnya. Konsumsi sildenafil bersama nitrat seperti nitroglycerin dapat menyebabkan penurunan tekanan darah yang signifikan sehingga memicu efek samping serius, terutama gangguan kardiovaskular. Sementara untuk pengobatan
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